![]() ![]() Mapping of 42 known pathogenic mutations onto the homology-modeled ACAD9 structure provides structural insights into pathomechanisms of CI deficiency.ĪCAD9 was first identified as a member of the acyl-CoA dehydrogenase family catalyzing the α, β-dehydrogenation of fatty acyl-CoA thioesters, the first step of the fatty acid β-oxidation cycle ( Zhang et al., 2002). Binding of ECSIT at the ETF binding site in the amino-terminal domain of ACAD9 is consistent with observed loss of FAD and enzymatic activity and demonstrates that the two functions of ACAD9 are mutually exclusive. Molecular modeling and small-angle X-ray scattering studies identified intra-complex interaction sites and binding sites for other assembly factors. Binary complexes are unstable and aggregate easily, while the ACAD9/ECSIT/NDUFAF1 ternary complex is soluble and highly stable. ACAD9 binds to the carboxy-terminal half and NDUFAF1 to the amino-terminal half of ECSIT. ![]() Current studies examine the molecular mechanism of ACAD9/ECSIT/NDUFAF1interactions. ACAD9, ECSIT, and NDUFAF1 interact to form the core mitochondrial CI assembly complex. The dual function protein ACAD9 catalyzes α,β-dehydrogenation of fatty acyl-CoA thioesters in fatty acid β-oxidation and is an essential chaperone for mitochondrial respiratory complex I (CI) assembly. ![]()
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![]() ![]() In fact, every main protagonist somehow gets thrown into a compromising position in way or another. It flirts with their relationship by throwing those two into erotic moments. The episode immediately puts her into compromising positions whenever it gets the chance with her student, Ichiro Sato. Meet Kana Kojima, the high school teacher at Kawanua West. Anyone healthy male can understand what that implies, right? The first few episodes decorates this anime with fan service, suggestive camera shots, and even some “fluids”. It seems the show follows a path to get us to understand something about adults or perhaps more specifically, teachers. ![]() In fact, you’ll be checking off a list of ecchi content on the bucket list by the time the show is over.īut what’s wrong with a show like this? Don’t we have enough fan service nowadays that all over the place each season anyway? Well, that’s true but it’s more tempting to say this show is nothing short than a sex education in disguise. ![]() The groans, sexy moans, and those colorful choreographed camera shots are what you’ll see all the way for each The plot is hardly noticeable as you’ll be far too distracted into the fan service than anything else. To put in the most straightforward way possible, this show is fan service fest dealing with rouchy, unbridled ecchi. Somehow, it got announced for an anime adaptation because why the hell not. The manga is nothing short of guilty pleasure that borderlines on hentai while containing immense amount of ecchi content and nudity. Truth be told, I don’t even know why the hell I decided to watch this show. ![]() ![]() Wide-step ladders have a 4' wide rounded step for more stability and comfort. ![]() DOCKMATE WIDE STEP DOCK LIFT LADDERS FOR FREEDUE TO SIZE AND PACKING DIMENSIONS THIS PRODUCT DOES NOT QUALIFY FOR FREE SHIPPING. capacity 21' wide ladder, 4' wide steps Specs Unit Weight 28.00 lb Brand Dockmate MFG Part No. 319.00 A1A5WLFT 5 Step Wide Step Lifting Dock Ladders A1A Dock Products 5 Step Wide Step Lifting Dock Ladder, Wide 3.5' Steps, Aluminum. Extra strong aluminum alloy Retractable ladder stows above the water line Corrosion-resistant 750-lb. Dock Edge + Welded Fixed Wide Step Dock Ladder, 4 Steps, Aluminum. Double rung locking mechanism keeps the ladder stable when climbing out of the water. Wide-step ladders have a 4' wide rounded step for more stability and comfort. Tommy Docks are designed to be the highest quality, most user-friendly boat dock. nice wide steps, handrails for added assistance, flip up - ladder rotates 180 degrees and rests safely on your dock, 500 lb capacity, and a relaxed 55 degree. : Dockmate Stationary Wide-Step Dock Ladder, 5-Step : Sports & Outdoors. Our dock ladder features extra wide traction-molded steps and tall handles to allow you to climb out of the water easily and upright in comfort. /rebates/&.com252fdockmate-wide-step-dock-lift-ladder-5-step-736368. Click here to shop for the 5 Rung Aluminum Lifting Ladder - 4 Wide Step. capacity 21' wide ladder, 4' wide steps Specs Unit Weight 28.35 lb Brand Dockmate MFG Part No. ![]() ![]() This Wide-Step Pontoon Dock Ladder is available in 3, 4, 5, 6, and 7-Step options! This Aluminum Stationary Dock Ladder is made from heavy duty Anodized Aluminum, and while it is lightweight itself, it can hold up to 750 lbs of weight. Wide-step ladders have a 4' wide rounded step for more stability and comfort. DJV 3-7W Wide-Step Stationary Dock Ladder ![]() ![]() ![]()
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With a focus on collaboration and agility, Teams is a core part of how the BrightWork Marketing team works together. Microsoft has created excellent training resources for Teams on their website and within the tool itself, including a bot, so do use these guides. TASK PLANNER EXCEL FULLOutlining the full functionality of Teams would take a few articles. This way, you can easily combine the functionality of BrightWork with chat, video calls, and more in Teams. The link to your project site will appear as a tab in Teams. Simply click the ‘Website’ icon above, fill in the short form, and add your link. If you are using SharePoint or BrightWork to manage projects, you can easily add a link to a project site to the relevant team. Microsoft Teams integrates with a wide range of Microsoft and third-party apps so your team can bring project information together in one place. TASK PLANNER EXCEL SOFTWAREIf you are accessing Teams via Microsoft 365, you can use the web app or download the software to your desktop.Ĭreating a new team is straightforward – simply click ‘create team’ underneath the list of available teams and complete the relevant information. Each team has a SharePoint Team Site, Office 365 Group, and shared OneNote. Teams is made up of teams – a collection of people, conversations, files, and tools – and channels – a discussion within the team focused on a particular topic like a project. Teams is built on the Office 365 Groups framework, bringing together various collaboration tools and options in one place. Robust security and privacy capabilities.Integration with third-party apps and connectors.Teams will replace Skype for Business in July 2021 as a tool for calls, video conferences, and meetings for Microsoft 365 users. Released to the public in early 2017, Microsoft Teams is a Slack-like app within Microsoft 365 that provides a chat-based workspace for teams to talk and collaborate. Overall, Planner is a great way to manage personal work and simple projects but isn’t robust enough for large or complex projects. Notifications for upcoming tasks were only sent 24 hours before the task was due, which led to missed deadlines.What may have been intended for one person can escalate into a group discussion, distracting people from their tasks! ![]()
![]() ![]() Using a badly configured (or badly written) browser add-on for blocking content.Running a "scraper" or "downloader" program that either does not identify itself or uses fake headers to elude detection.Using a script or add-on that scans GameFAQs for box and screen images (such as an emulator front-end), while overloading our search engine.There is no official GameFAQs app, and we do not support nor have any contact with the makers of these unofficial apps. Continued use of these apps may cause your IP to be blocked indefinitely. This triggers our anti-spambot measures, which are designed to stop automated systems from flooding the site with traffic. Some unofficial phone apps appear to be using GameFAQs as a back-end, but they do not behave like a real web browser does.Using GameFAQs regularly with these browsers can cause temporary and even permanent IP blocks due to these additional requests. If you are using Maxthon or Brave as a browser, or have installed the Ghostery add-on, you should know that these programs send extra traffic to our servers for every page on the site that you browse.The most common causes of this issue are: That means with an increase in service pressure schedule number will increase, which is a pipe wall thickness designator.ĪSME B36.10M-2015: Welded and Seamless Wrought Steel PipeĪSME B36.Your IP address has been temporarily blocked due to a large number of HTTP requests. Look at the above formula of schedule number allowable stress for material at a given temperature is fixed. Schedule 80 pipe is thicker than schedule 40 pipe. Now, can you tell me which is thicker, schedule 40 or 80 pipes? In simple words, you can say that for a given material, schedule 40 pipes can withstand a certain amount of pressure. Schedule 40 is nothing but a pipe thickness designator. You can see the pipe schedule calculation formula below To simplify the ordering of the pipe ASME committee has developed Schedule Number, which is based on modified Barlow’s wall thickness formula.ĭefinition of Schedule Number: The schedule number indicates an approximate value of the expression 1000 x P/S where P is the service pressure and S is the allowable stress, both expressed in pounds per square inch. The pipe schedule is the way pipe wall thickness is mentioned. From 6” to 42”, it increases by 2” step and after that in 4”. There is no change in other dimensions when you use DN.įrom this table, you can see that initially pipe size increases by ¼ than ½ and then by 1”. Check the below table for easy understanding. You can get any NPS to DN by multiplying it by 25. Here, you have to note that DN shows pipe sizes differently than NPS.Ģ” pipe is simply mentioned as DN 50. ![]() What is DN (Diameter Nominal) Pipe Size?ĭN or Diameter Nominal is an International designation (SI or Matric Designator) and a European NPS equivalent to show pipe sizes. So when someone says 25nb pipe or 50nb pipe, basically they are talking about DN. ![]() I have also seen that when pipe dimensions are shown in mm (DN) people refer to pipe sizes in NB. NB is also an American way to refer to pipe dimensions. As such, there is no difference between NB and NPS. NPS is frequently referred as an NB (Nominal Bore).
![]() ![]() For the next 150 years it was part of the western Qarakhanid khanate, ruled by descendants of the Ilak Nasr. In 389/999 Bukhara was occupied by the Ilak (Ilig) Nasr b. The city had expanded, although geographers still criticize it as an unsanitary and crowded place. ![]() In this century, an outer wall with eleven gates was built. Aḥmad (301-33/914-43) built a palace and where the dīvāns of the administration were situated. ![]() To its east, dividing it from the sahrestan, was the Registan, an open, sandy space where Amir Naṣr b. The citadel contained the palace and the original mosque of Qotayba b. Geographers from the Samanid period mention the division of the city in a citadel (kohandez), the town proper (sahrestan) and a suburb (rabat). A passage by Taalebi, the famous scholar of Nisapur, praises Bukhara in the era of the Samanids as “the focus of splendour, the Kaba of the empire, the meeting-place of the unique figures of the age, the rising-place of the stars of the literary men of the world, and the forum for the outstanding personages of the time”. Bukhara enjoyed a period of prosperity lasting for 150 years and under the patronage of the Samanid amirs served as a cultural centre for Arabic learning and Persian literature. the notables of Bukhara asked the Samanid ruler of Samarqand and Farḡāna Nasr b.Ahmad for help, who in 260/874 sent his younger brother Ismail to the city. Solayman Ṭusi built walls to protect Bukhara against Turkish attacks. In 166/782, the governor of Khorasan Fażl b. In 94/712-13 he erected the first mosque in Bukhara within the citadel, on the site of a former Buddhist or Zoroastrian temple. Moslem Baheli, who after arduous campaigns in Sogdia (87-90/706-09) overcame the resistance of the Bukharans and their Turkish allies and placed an Arab garrison in the city, forcing every home owner to share his residence with Arabs. Permanent Arab control in the city was established by Qotayba b. She had to submit and to pay a tribute of a million dirhams and 4,000 slaves. Bukhara was ruled by a woman, Katun, as regent for her infant son. Arab armies first appeared before Bukhara in the caliphate of Moawia, after Obayd-Allāh b. There are no reports of a city in the area of Bukhara at the time of Alexander the Great.įrom the Arab invasions to the Mongols Īt the time of the Arab conquests, Bukhara was ruled by the Sogdian dynasty of the Bokar-kodats. AD, the date of the first coins with Sogdian writing in an alphabet derived from Aramaic. The history of Bukhara can be traced back to the 4th or 5th cent. Siavash's father sent Rostam, the legendary Persian hero to Turan and Rostam brought Ferganiza (Farangis) and their son Kai Khosrow back to Persia. Later, Siavash was accused that he wanted to overthrow King Afrasiab and was executed in front of his wife. Afrasiab, the King of Samarkand, married his daughter Ferganiza(Farangis) to him and granted him a vassal kingdom in the oasis of Bukhara. After the treason of his stepmother Sudabeh, who accused him that he wanted to seduce her and betray his father, Siavash went into exile to Turan. Understand History Legend of Siavash Īccording to the legend Bukhara was founded by King Siavash, a legendary Persian prince from the beginnings of the Persian Empire. The famous poets Narshahi, Rudaki Dakiki and others have played an important role in the development of Bukhara. Such buildings as Poi - Kalan, Kosh Madras, mausoleum of Ismail Samoni, minaret of Kalyan and others were built 2,300 years ago, and today are popular with tourists. Bukhara, "The city of museums", contains more than 140 architectural monuments of the Middle Ages. In Sanskrit the word Bukhara means "abbey". The city centre is a UNESCO World Heritage Site. Bukhara (also spelled Bokhara, Bukhoro, or Buxoro) in Uzbekistan was historically one of the great trading cities along the Silk Road. ![]() ![]() The rear heel pad is replaceable, which is something that is much appreciated. ![]() For the sole, you get the 10’s 80% composite/20% carbon sole, but Time adds a carbon fiber plate at the cleat to increase stiffness. The closure is a single Boa IP1 dial at the top with a velcro strap at the bottom. The 12 benefits from the same upper as the 15, a seamless upper made from a mix of microfiber and multiple panels of mesh to make them extremely breathable. Sitting in the middle of the line, the 12 is definitely a blend of the 10 and 15. The 12 Time uses a 80% composite/20% carbon sole with a carbon plate on the OSMOS 12 From there, Time worked with their R&D teams to create the new line. The Italian brand makes ski boots, among other items, and had a wealth of data on foot shapes to help create the lasts for the OSMOS. When Time began working on shoes again, they turned to the experience of their parent company Rossignol. #Time osmos 15 road cycling shoes fullThe soles range from an 80% composite/20% carbon mix on the 10 to a full carbon sole on the 15 and all three models include a version of Time’s Sensor2 insoles. Each shoe features at least one Boa IP1 dial for the closure (one on the 10 and 12, and two on the 15). The look of each shoe is pretty similar, with the 12 and 15 gaining large mesh panels to increase ventilation substantially. The OSMOS comes in three levels, the entry 10, mid-level 12, and range topping 15. OSMOS Line Overview There is plenty of ventilation with all of the mesh on the OSMOS 12. We’ve put the mid-level shoe, the 12, through a season of riding, and found it to be a capable shoe with great ventilation. With three different levels, they have a shoe to fit the needs of many different road riders. Very airy, they are limited to when it’s hot.Time stepped back into the shoe world after nine years with the launch of their OSMOS road line earlier in 2019. The good comfort makes them possible to use on long distances. The Time Osmos 15 are good high-performance carbon shoes. ![]() In terms of durability, after using for many months, we didn’t see any weak points. Powerful adjustment so be careful not to overdo it. ![]() The two discs can be easily grasped, even with gloves on. The Boa system handling is as usual very practical and efficient. When the temperature drops sharply, you must either cover them with a bootie or use a different pair because they are too cold. With all their ventilation, the Time Osmos 15 are ideal for outings in a hot weather. The Time Osmos 15 design is successful, yet we can’t help but notice the tongue’s two notches: not very pretty. Pay attention to the instep area, because despite the fact that they have a comfortable tongue, the Boa system cable can cause a pressure point on top of the foot if you tighten it too much (ankle fold).Īnother point, they make a slight noise, they squeak (the tongue junction?) Like ski touring boots, which make a little noise when in full effort and it’s quite annoying. We tested these shoes with Time Xpro 10 pedals, what a treat!ĭuring long outings, we didn’t notice any friction or heat rubbing at the heels or forefoot. There’s no doubt that all the cyclist’s energy is transmitted through the pedals. The output is very good, both pushing and pulling. So you have a lightweight shoe, 175g without the cleats in size 42.5, 185 grams with the cleats. They’ve done a great job with carbon fiber. Let’s move on to the Time Osmos 15’s major highlight: its sole. We have also had easier shoes to put on that open wider, like the Scott Road RC. In short, you need to reposition the heels of your socks so you don’t have any extra thickness. ![]() The quid pro? When you put them on your socks don’t slip inside the shoes and their heels are held by the non-slip fabric. The heel is well pinched using a flexible and non-slip fabric, the heel remains firmly held when pedaling. The metatarsal zone is limited and the overall foot envelopment is very good. We were able to test them for a long time out on the road, on long routes but also on single-speed bikes where sole rigidity and the notion of “pulling” are fundamental.Ĭontrary to what we have read on some blogs, these shoes are narrow, especially around the forefoot (very snug fitting). The Time Osmos 15, at 300 euros, is the top-end model from the brand that owns the Rossignol group. ![]() ![]() The virtual event is broadcast every Monday night on Facebook live and Twitch with performances from drag artists and commentary from Nova, who is known for her sharp humor. The iconic Cassie Nova of the Rose Room at Station 4 in Dallas hosts a virtual rendition of her weekly FreakShow. Looking for a quarantined alternative to these events? Say no more. Social distancing guidelines will be enforced. This week’s contestants include Deja Devanesse, Miss Venom, Jeffrey Hunter and more with host SissyPop 2.0. Masks are required and hand sanitizer is readily available.Įvery Monday, Marty’s Live hosts weekly show Drag on Tap, where drag artists participate in a competition that is sure to bring the house down. The bar has strictly enforced social distancing measures requiring patrons to be seated at all times. Hosted by Frida Monet and Chanel Lamasters, the drag event has offered performances from local artists like Mulan Alexander and Serene Storm. The cover is $10, and music is provided by Dezi 5.įort Worth’s largest LGBTQ nightclub, The Urban Cowboy, presents The Sh*t Show every Friday night. #BLEACH CLICK AND DRAG FREE#Kennedy Davenport is a busy lady and is joining fierceness with local artist Bleach - who has remained active during the pandemic with Lady Gaga-themed livestreams - by hosting a socially distant brunch show at The Free Man in Deep Ellum. Performers are required to wear face shields and Marty’s Live will adhere to social distancing regulations.Īll Tea, No Shade Brunch with Kennedy Davenport and Bleach Contestants are encouraged to perform original and creative content in order to impress the legendary Davenport with the winner receiving $200 cash. This week’s special guest is local drag artist Nicole O’Hara. #BLEACH CLICK AND DRAG GENERATOR#Our Superhero Name Generator will give you 20 names every time you click. Best bet would be to foil those lengths if you need a lot of lift. But it really depends how dark the pieces you are working with and how many levels need to be lifted. Hosted by RuPaul’s Drag Race contestant and Dallas native Kennedy Davenport, the competition showcase hosts local drag queens, drag kings, musicians and a wide variety of queer artists at Marty’s Live in Dallas. The Hero Creator game uses a simple drag-and-drop interface, which allows you. After applying lightener to roots, Ill let that develop about 20 minutes and then paint lightener directly on dark areas and let develop in open air. Kennedy Davenport presents The All Around Talent Competition Showcase Here are just a few drag shows that are coming up this week. The pandemic still looms, but there are still ways to enjoy a night out while supporting local queer artists. Dallas queer bars are opening under tightened regulations, and in-person drag shows have returned with queens hungry to serve lewks and make their coin. Local entertainment businesses, from concert venues to drag queens, are adapting to a new world. ![]() ![]() ![]() You can even check what difference the Bass Mono switch makes! This makes it a perfect tool to check mono compatibility with. It also introduces a Mono switch and a Bass Mono switch, which allows you to mono all frequencies below a certain frequency. Improved audio effects and Max for Live effects This is a faster way of saving your favourite presets and samples - you don’t have to copy them over to custom folders. You can assign colour tags to devices or sounds and you’ll find it under “Browser collections”. Live 10 introduces a simple way of organising your browser. This allows you to work on ends of pads without the need to play the clip from the very start. Now you can start playing the track in the middle of a MIDI note and it’s going to be triggered. Before, MIDI notes used to be triggered only if they were played from the start. This feature is useful when you’re working ends of long sustained MIDI notes, like pads. The colours of the notes are the same clip colours so you can tell which notes belong to which clip. ![]() All you need to do is select a clip on each of these tracks and the notes will appear in Clip View. This means that you can edit your lead melody, pad and bass notes all at once. With Live 9 you can edit multiple MIDI clips at once. In case you want to use a different part than Live’s guess, you can always go back in time in the clip.Ī “captured” part with previously played parts on the left. All you need to do is hit the “Capture” button after you play something you want to save and it will be saved automatically. To avoid this problem, Live now secretly records everything you play, even if you don’t hit record. After that I couldn’t play it the same way anymore and I would get frustrated. This used to happen to me all the time - I would improvise and accidentally find something awesome, but then I’d find out I forgot to hit record before playing. It could be useful to subtly warm up a vocal, add drive to a guitar part or add harmonics to a bass synth. This effect gives you the sound of overdrive, distortion and fuzz guitar pedals. It’s got plenty of features including noise, modulation, saturation and even reverb. ![]() It’s a fancy new delay effect which combines the classic analog feel with modern digital sound. It also allows you to dial in bass boom at a specific frequency with decay control for extra character. Drum Buss combines these effects into one, allowing you to give character to your drums more easily. The most often used effects on drum groups are compressors, saturators and transient designers. Other features include morphing wavetables, a Sub section and two filters - one for each oscillator. Its modulation section consists of two envelopes and two LFOs which can be mapped to any parameter in the synth. It’s similar to Xfer Serum - it uses wavetables for its two oscillators. Live 10 introduces a powerful built-in synthesizer. ![]() |
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